From fish to man: Research reveals how fins became legs

Dec. 10, 2012 ? Vertebrates' transition to living on land, instead of only in water, represented a major event in the history of life. Now, researchers reporting in the December issue of the Cell Press journal Developmental Cell provide new evidence that the development of hands and feet occurred through the gain of new DNA elements that activate particular genes.

"First, and foremost, this finding helps us to understand the power that the modification of gene expression has on shaping our bodies," says Dr. Jos? Luis G?mez-Skarmeta of the CSIC-Universidad Pablo de Olavide-Junta de Andaluc?a, in Seville, Spain. "Second, many genetic diseases are associated with a 'misshaping' of our organs during development. In the case of genes involved in limb formation, their abnormal function is associated with diseases such as synpolydactyly and hand-foot-genital syndrome."

In order to understand how fins may have evolved into limbs, researchers led by Dr. G?mez-Skarmeta and his colleague Dr. Fernando Casares at the same institute introduced extra Hoxd13, a gene known to play a role in distinguishing body parts, at the tip of a zebrafish embryo's fin. Surprisingly, this led to the generation of new cartilage tissue and the reduction of fin tissue -- changes that strikingly recapitulate key aspects of land-animal limb development. The researchers wondered whether novel Hoxd13 control elements may have increased Hoxd13 gene expression in the past to cause similar effects during limb evolution. They turned to a DNA control element that is known to regulate the activation of Hoxd13 in mouse embryonic limbs and that is absent in fish.

"We found that in the zebrafish, the mouse Hoxd13 control element was capable of driving gene expression in the distal fin rudiment. This result indicates that molecular machinery capable of activating this control element was also present in the last common ancestor of finned and legged animals and is proven by its remnants in zebrafish," says Dr. Casares.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

---

Story Source:

The above story is reprinted from materials provided by Cell Press, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Renata Freitas, Carlos G?mez-Mar?n, Jonathan?Mark Wilson, Fernando Casares, Jos??Luis G?mez-Skarmeta. Hoxd13 Contribution to the Evolution of Vertebrate Appendages. Developmental Cell, 2012; 23 (6): 1219 DOI: 10.1016/j.devcel.2012.10.015

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/8ousWo2SoZo/121210124521.htm

jaws first night ball drop dick clark new years eve brock lesnar vs alistair overeem times square new years eve liquor store